Biochem/physiol Actions

Reversible: no

Primary TargetP2Y₁₂

General description

A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y₁₂ receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Liu, O., et al. 2012. PLoS One.7, e51707.r>Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.

Packaging

5 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)